Michael has some good points, but unless I've missed it, we know next to nothing about your site and method of backup.
Stabs in the dark:
Is the i/o path from vm to esx very short?
Have you tuned the NBU master/media servers?
Is your backup path independent of the network/normal i/o and disk i/o?
There are hundreds of other possibilities depending on your setup.
Cheers, Wayne
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