Rusty and others have pointed out the best methods in tackling your issue. There is another option which is new but it requires a Symantec 5xxx Appliance or similar disk using PureDisk. It is called Optimized Synthetic Backups. NetBackup Admin Guide vol 1. (pg. 824)
I had a 1.5 Tb 7million+ file behemoth taking 20 hours to backup to an Appliance with Accelerator enabled.
Switching to Optimized, that backup in now only takes 50 minutes. (one note, you can't enable Accelerator within the Policy )
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